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Article

Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination.

The Journal of cell biology - 27 Oct 2003

Chun Soo Jin, Rasband Matthew N, Sidman Richard L, Habib Amyn A, Vartanian Timothy

Abstract excerpt

Early steps in myelination in the central nervous system (CNS) include a specialized and extreme form of cell spreading in which oligodendrocytes extend large lamellae that spiral around axons to form myelin. Recent studies have demonstrated that laminin-2 (LN-2; alpha2beta1gamma1) stimulates oligodendrocytes to extend elaborate membrane sheets in vitro (cell spreading), mediated by integrin alpha6beta1. Although...

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Identifiers

PMID: 14581460
DOI: 10.1083/jcb.200304154
PMCID: PMC2173507

Genes

ILK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Integrin-linked kinase is required for laminin-2-induced oligodendrocyte cell spreading and CNS myelination.PMID 14581460Read ↗

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