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Article

Mechanical and non-mechanical functions of Dystrophin can prevent cardiac abnormalities in Drosophila.

Experimental gerontology - 1 Jan 2014

Taghli-Lamallem Ouarda, Jagla Krzysztof, Chamberlain Jeffrey S, Bodmer Rolf

Abstract excerpt

Dystrophin-deficiency causes cardiomyopathies and shortens the life expectancy of Duchenne and Becker muscular dystrophy patients. Restoring Dystrophin expression in the heart by gene transfer is a promising avenue to explore as a therapy. Truncated Dystrophin gene constructs have been engineered and shown to alleviate dystrophic skeletal muscle disease, but their potential in preventing the development of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24231130
DOI: 10.1016/j.exger.2013.10.015
PMCID: PMC4340692

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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