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Disrupted mechanobiology links the molecular and cellular phenotypes in familial dilated cardiomyopathy

19 Aug 2019

Abstract excerpt

Familial dilated cardiomyopathy (DCM) is a leading cause of sudden cardiac death and a major indicator for heart transplant. The disease is frequently caused by mutations of sarcomeric proteins; however, it is not well understood how these molecular mutations lead to alterations in cellular organization and contractility. To address this critical gap in our knowledge, we studied the molecular and cellular...

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PMID: 31427533
DOI: 10.1073/pnas.1910962116

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