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Article

Dilated cardiomyopathy mutations in three thin filament regulatory proteins result in a common functional phenotype.

The Journal of biological chemistry - 5 Aug 2005

Mirza Mahmooda, Marston Steven, Willott Ruth, Ashley Christopher, Mogensen Jens, McKenna William, Robinson Paul, Redwood Charles, Watkins Hugh

Abstract excerpt

Dilated cardiomyopathy (DCM), characterized by cardiac dilatation and contractile dysfunction, is a major cause of heart failure. Inherited DCM can result from mutations in the genes encoding cardiac troponin T, troponin C, and alpha-tropomyosin; different mutations in the same genes cause hypertrophic cardiomyopathy. To understand how certain mutations lead specifically to DCM, we have investigated their effect...

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Source

Identifiers

PMID: 15923195
DOI: 10.1074/jbc.M412281200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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