Article
Identification of a pan-cancer oncogenic microRNA superfamily anchored by a central core seed motif.
Nature communications - 1 Jan 2013
Hamilton Mark P, Rajapakshe Kimal, Hartig Sean M, Reva Boris, McLellan Michael D, Kandoth Cyriac, Ding Li, Zack Travis I, Gunaratne Preethi H, Wheeler David A, Coarfa Cristian, McGuire Sean E
Abstract excerpt
MicroRNAs modulate tumorigenesis through suppression of specific genes. As many tumour types rely on overlapping oncogenic pathways, a core set of microRNAs may exist, which consistently drives or suppresses tumorigenesis in many cancer types. Here we integrate The Cancer Genome Atlas (TCGA) pan-cancer data set with a microRNA target atlas composed of publicly available Argonaute Crosslinking Immunoprecipitation...
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