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Article

A c-Myc-MicroRNA functional feedback loop affects hepatocarcinogenesis

7 Feb 2013

Abstract excerpt

UNLABELLED: c-Myc (Myc) plays an important role in normal liver development and tumorigenesis. We show here that Myc is pathologically activated in and essential for promoting human hepatocellular carcinoma (HCC). Myc induces HCC through a novel, microRNA (miRNA)-mediated feedback loop comprised of miR-148a-5p, miR-363-3p, and ubiquitin-specific protease 28 (USP28). Myc directly binds to conserved regions in the...

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PMID: 23389829
DOI: 10.1002/hep.26302

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