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Article

Mutations in MAPT give rise to aneuploidy in animal models of tauopathy.

Neurogenetics - 1 Mar 2014

Rossi Giacomina, Conconi Donatella, Panzeri Elena, Paoletta Laura, Piccoli Elena, Ferretti Maria Giulia, Mangieri Michela, Ruggerone Margherita, Dalprà Leda, Tagliavini Fabrizio

Abstract excerpt

Tau is a major microtubule-associated protein in brain neurons. Its misfolding and accumulation cause neurodegenerative diseases characterized by brain atrophy and dementia, named tauopathies. Genetic forms are caused by mutations of microtubule-associated protein tau gene (MAPT). Tau is expressed also in nonneural tissues such as lymphocytes. Tau has been recently recognized as a multifunctional protein, and in...

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Source

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Identifiers

PMID: 24218087
DOI: 10.1007/s10048-013-0380-y
PMCID: PMC3968519

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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