Article
Developmental Expression of 4-Repeat-Tau Induces Neuronal Aneuploidy in Drosophila Tauopathy Models.
Scientific reports - 23 Jan 2017
Malmanche Nicolas, Dourlen Pierre, Gistelinck Marc, Demiautte Florie, Link Nichole, Dupont Cloé, Vanden Broeck Lies, Werkmeister Elisabeth, Amouyel Philippe, Bongiovanni Antonino, Bauderlique Hélène, Moechars Dieder, Royou Anne, Bellen Hugo J, Lafont Frank, Callaerts Patrick, Lambert Jean-Charles, Dermaut Bart
Abstract excerpt
Tau-mediated neurodegeneration in Alzheimer's disease and tauopathies is generally assumed to start in a normally developed brain. However, several lines of evidence suggest that impaired Tau isoform expression during development could affect mitosis and ploidy in post-mitotic differentiated tissue. Interestingly, the relative expression levels of Tau isoforms containing either 3 (3R-Tau) or 4 repeats (4R-Tau)...
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