Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations in MAPT gene cause chromosome instability and introduce copy number variations widely in the genome.

Journal of Alzheimer's disease : JAD - 1 Jan 2013

Rossi Giacomina, Conconi Donatella, Panzeri Elena, Redaelli Serena, Piccoli Elena, Paoletta Laura, Dalprà Leda, Tagliavini Fabrizio

Abstract excerpt

In addition to the main function of promoting polymerization and stabilization of microtubules, other roles are being attributed to tau, now considered a multifunctional protein. In particular, previous studies suggest that tau is involved in chromosome stability and genome protection. We perform...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line, Transformed
Share to Cells, Cultured
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromosomal Instability

Share to DNA Copy Number Variations

Share to Fibroblasts

Share to Genome, Human

Share to tau Proteins

Source

Identifiers

PMID: 23047372
DOI: 10.3233/JAD-2012-121633

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Prepared record publication-23047372-2026-09-05.1. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in MAPT gene cause chromosome instability and introduce copy number variations widely in the genome.PMID 23047372Read ↗

Tau and DNA Damage in NeurodegenerationSemantic proximity Read ↗

A new function of microtubule-associated protein tau: involvement in chromosome stability.Semantic proximity Read ↗

Mutations in MAPT give rise to aneuploidy in animal models of tauopathy.Semantic proximity Read ↗

P301L tau mutation leads to alterations of cell cycle, DNA damage response and apoptosis: Evidence for a role of tau in cancer.Semantic proximity Read ↗

Tau Mutations Serve as a Novel Risk Factor for Cancer.Semantic proximity Read ↗

Frontotemporal lobar degeneration: old knowledge and new insight into the pathogenetic mechanisms of tau mutationsSemantic proximity Read ↗

Emerging Evidences for an Implication of the Neurodegeneration-Associated Protein TAU in CancerSemantic proximity Read ↗

Mitotic defects lead to neuronal aneuploidy and apoptosis in frontotemporal lobar degeneration caused by MAPT mutations.Semantic proximity Read ↗

Novel Functions of the Neurodegenerative-Related Gene Tau in CancerSemantic proximity Read ↗

Partial deletion of theMAPTgene: A novel mechanism of FTDP-17Semantic proximity Read ↗

Failure of DNA double-strand break repair by tau mediates Alzheimer’s disease pathology in vitroSemantic proximity Read ↗

Cytogenetic alterations in lymphocytes of Alzheimer's disease and Parkinson's disease patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.