Dopa-decarboxylase gene polymorphisms affect the motor response to L-dopa in Parkinson's disease.

doi:10.1016/j.parkreldis.2013.10.017

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Article

Dopa-decarboxylase gene polymorphisms affect the motor response to L-dopa in Parkinson's disease.

Parkinsonism & related disorders - 1 Feb 2014

Devos David, Lejeune Stéphanie, Cormier-Dequaire Florence, Tahiri Khadija, Charbonnier-Beaupel Fanny, Rouaix Nathalie, Duhamel Alain, Sablonnière Bernard, Bonnet Anne-Marie, Bonnet Cecilia, Zahr Noel, Costentin Jean, Vidailhet Marie, Corvol Jean-Christophe

Abstract excerpt

BACKGROUND: In Parkinson's disease (PD), the response to L-dopa is highly variable and unpredictable. The major pathway for dopamine synthesis from L-dopa is decarboxylation by aromatic L-amino acid decarboxylase (AAAD, encoded by the DDC gene). OBJECTIVE: To determine the motor response to L-dopa in PD patients as a function of the DDC gene promoter polymorphisms (rs921451 T > C polymorphism (DDC(T/C)) and...

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PMID: 24216088
DOI: 10.1016/j.parkreldis.2013.10.017

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