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Article

Two novel variants in the DOPA decarboxylase gene: association with bipolar affective disorder.

Molecular psychiatry - 1 Nov 1999

Børglum A D, Bruun T G, Kjeldsen T E, Ewald H, Mors O, Kirov G, Russ C, Freeman B, Collier D A, Kruse T A

Abstract excerpt

DOPA decarboxylase (DDC), also known as aromatic L-amino acid decarboxylase (AADC), is an enzyme involved in the synthesis of the important neurotransmitters dopamine, norepinephrine, and serotonin. In addition, it participates in the synthesis of trace amines; compounds suggested to act as endogenous modulators of central neurotransmission. Thus, DDC is regarded as a potential susceptibility gene for a variety...

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Identifiers

PMID: 10578236
DOI: 10.1038/sj.mp.4000559

Genes

DDC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Two novel variants in the DOPA decarboxylase gene: association with bipolar affective disorder.PMID 10578236Read ↗

Association study between two variants in the DOPA decarboxylase gene in bipolar and unipolar affective disorder.Semantic proximity Read ↗

Possible parent-of-origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder.Semantic proximity Read ↗

Novel variants in aromatic L-amino acid decarboxylase deficiency: Case report of sisters with mild phenotype.Semantic proximity Read ↗

Dopa decarboxylase gene polymorphisms and attention deficit hyperactivity disorder (ADHD): no evidence for association in the Irish population.Semantic proximity Read ↗

Prevalence of DDC genotypes in patients with aromatic L-amino acid decarboxylase (AADC) deficiency and in silico prediction of structural protein changes.Semantic proximity Read ↗

Investigation of two variants in the DOPA decarboxylase gene in patients with autism.Semantic proximity Read ↗

Intronic variants in the dopa decarboxylase (DDC) gene are associated with smoking behavior in European-Americans and African-Americans.Semantic proximity Read ↗

Next-generation sequencing reveals alternative L-DOPA decarboxylase (DDC) splice variants bearing novel exons, in human hepatocellular and lung cancer cells.Semantic proximity Read ↗

Haplotype analysis indicates an association between the DOPA decarboxylase (DDC) gene and nicotine dependence.Semantic proximity Read ↗

When dysphoria is not a primary mental state: A case report of the role of the aromatic L-aminoacid decarboxylase.Semantic proximity Read ↗

Molecular cloning of genomic DNA and chromosomal assignment of the gene for human aromatic L-amino acid decarboxylase, the enzyme for catecholamine and serotonin biosynthesisSemantic proximity Read ↗

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