Article
Dopamine beta-hydroxylase -1021C>T association and Parkinson's disease.
Parkinsonism & related disorders - 1 Nov 2008
Ross Owen A, Heckman Michael G, Soto Alexandra I, Diehl Nancy N, Haugarvoll Kristoffer, Vilariño-Güell Carles, Aasly Jan O, Sando Sigrid, Gibson J Mark, Lynch Timothy, Krygowska-Wajs Anna, Opala Grzegorz, Barcikowska Maria, Czyzewski Krzysztof, Uitti Ryan J, Wszolek Zbigniew K, Farrer Matthew J
Abstract excerpt
A single nucleotide polymorphism in the promoter region of the dopamine beta-hydroxylase gene (DBH -1021C>T; rs1611115) is reported to regulate plasma enzyme activity levels. This variant has also been the focus of two large association studies in Parkinson's disease yielding conflicting results. We examined this association in four Caucasian patient-control series (n=2696). A modest protective association was...
Topics
- Adult
- Aged
- Aged, 80 and over
- Case-Control Studies
- Dopamine beta-Hydroxylase
- Female
- Gene Frequency