Different dynamic movements of wild‐type and pathogenic <scp>VCP</scp>s and their cofactors to damaged mitochondria in a <scp>P</scp>arkin‐mediated mitochondrial quality control system

Abstract excerpt

VCP/p97 is a hexameric ring-shaped AAA(+) ATPase that participates in various ubiquitin-associated cellular functions. Mis-sense mutations in VCP gene are associated with the pathogenesis of two inherited diseases: inclusion body myopathy associated with Paget's disease of the bone and front-temporal dementia (IBMPFD) and familial amyotrophic lateral sclerosis (ALS). These pathogenic VCPs have higher affinities...

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