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Reduced Genetic Heterogeneity for Stable Bioproduction by Harnessing the Bias and Mechanism of Mutation.

Microbial biotechnology - 1 Jun 2025

Cao Yanting, Wu Yaokang, Lv Xueqin, Li Jianghua, Liu Long, Du Guocheng, Chen Jian, Liu Yanfeng

Abstract excerpt

Microbial bioproduction is an important approach to realising green biomanufacturing. However, poor bioproduction stability caused by genetic heterogeneity is one of the important factors limiting its industrial-scale applications. Here, two methods have been developed to reduce genetic heterogeneity in Bacillus subtilis. SiteMuB (the site-dependent mutation bias) was proposed to enable stable genome integration...

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Topics

Bacillus subtilis
Genetic Heterogeneity
Metabolic Engineering
Mutation
Mutation Rate

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Identifiers

PMID: 40536140
DOI: 10.1111/1751-7915.70162
PMCID: PMC12177666

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