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Article

Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis.

Journal of cell science - 15 Jan 2014

Sato Takashi, Iwano Tomohiko, Kunii Masataka, Matsuda Shinji, Mizuguchi Rumiko, Jung Yongwook, Hagiwara Haruo, Yoshihara Yoshihiro, Yuzaki Michisuke, Harada Reiko, Harada Akihiro

Abstract excerpt

The small GTP-binding protein Rab8 is known to play an essential role in intracellular transport and cilia formation. We have previously demonstrated that Rab8a is required for localising apical markers in various organisms. Rab8a has a closely related isoform, Rab8b. To determine whether Rab8b can compensate for Rab8a, we generated Rab8b-knockout mice. Although the Rab8b-knockout mice did not display an overt...

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Identifiers

PMID: 24213529
DOI: 10.1242/jcs.136903
PMCID: PMC3898603

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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