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Article

Golgi-localized phosphatidylinositol 4-kinase β mediates Rab11a activation and trafficking to promote ciliogenesis.

Science advances - 5 Dec 2025

Wang Liwen, Sun Jia, Sun Shuang, Huang Zhenzhou, Liu Ying, Yan Shaodong, Sun Chunjiao, Feng Qian, Fu Wenxiang, Zhong Tao, Zhang Jingjing, Zhou Jun, Liu Peiwei

Abstract excerpt

Ciliogenesis requires an orchestrated interaction between the Golgi apparatus and centrioles via vesicle trafficking, yet this process is still poorly understood. Phosphatidylinositol 4-kinase β (PI4KB) is a conserved kinase that localizes to the Golgi for generating phosphatidylinositol 4-phosphate, an important lipid component related to cilium formation. Here, we demonstrate a previously uncharacterized...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41348894
DOI: 10.1126/sciadv.adw6910
PMCID: PMC12680052

Genes

PI4KB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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