Article
A large-scale screen for coding variants predisposing to psoriasis.
Nature genetics - 1 Jan 2014
Tang Huayang, Jin Xin, Li Yang, Jiang Hui, Tang Xianfa, Yang Xu, Cheng Hui, Qiu Ying, Chen Gang, Mei Junpu, Zhou Fusheng, Wu Renhua, Zuo Xianbo, Zhang Yong, Zheng Xiaodong, Cai Qi, Yin Xianyong, Quan Cheng, Shao Haojing, Cui Yong, Tian Fangzhen, Zhao Xia, Liu Hong, Xiao Fengli, Xu Fengping, Han Jianwen, Shi Dongmei, Zhang Anping, Zhou Cheng, Li Qibin, Fan Xing, Lin Liya, Tian Hongqing, Wang Zaixing, Fu Huiling, Wang Fang, Yang Baoqi, Huang Shaowei, Liang Bo, Xie Xuefeng, Ren Yunqing, Gu Qingquan, Wen Guangdong, Sun Yulin, Wu Xueli, Dang Lin, Xia Min, Shan Junjun, Li Tianhang, Yang Lin, Zhang Xiuyun, Li Yuzhen, He Chundi, Xu Aie, Wei Liping, Zhao Xiaohang, Gao Xinghua, Xu Jinhua, Zhang Furen, Zhang Jianzhong, Li Yingrui, Sun Liangdan, Liu Jianjun, Chen Runsheng, Yang Sen, Wang Jun, Zhang Xuejun
Abstract excerpt
To explore the contribution of functional coding variants to psoriasis, we analyzed nonsynonymous single-nucleotide variants (SNVs) across the genome by exome sequencing in 781 psoriasis cases and 676 controls and through follow-up validation in 1,326 candidate genes by targeted sequencing in 9,946 psoriasis cases and 9,906 controls from the Chinese population. We discovered two independent missense SNVs in IL23R...
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