Article
Current understanding of human genetics and genetic analysis of psoriasis.
The Journal of dermatology - 1 Mar 2012
Oka Akira, Mabuchi Tomotaka, Ozawa Akira, Inoko Hidetoshi
Abstract excerpt
During the past 5 years, genome-wide association studies (GWAS), primarily based on single nucleotide polymorphism markers, have identified many loci as potential psoriasis susceptibility regions. These studies appeared to provide strong evidence because the susceptibility genes are involved in the interleukin-23/T-helper 17 axis of psoriasis immunopathogenesis and/or skin barrier functions. However, the...
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