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Article

CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter.

Cell metabolism - 6 Jan 2015

Paupe Vincent, Prudent Julien, Dassa Emmanuel P, Rendon Olga Zurita, Shoubridge Eric A

Abstract excerpt

Mitochondrial calcium is an important modulator of cellular metabolism. CCDC90A was reported to be a regulator of the mitochondrial calcium uniporter (MCU) complex, a selective channel that controls mitochondrial calcium uptake, and hence was renamed MCUR1. Here we show that suppression of CCDC90A in human fibroblasts produces a specific cytochrome c oxidase (COX) assembly defect, resulting in decreased...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Electron Transport Chain Complex Proteins

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Source

Identifiers

PMID: 25565209
DOI: 10.1016/j.cmet.2014.12.004

Genes

MCU
MCUR1
COX10
TACO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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