Article
Transcriptional regulation of the rat bradykinin B2 receptor gene: identification of a silencer element.
Molecular pharmacology - 1 Dec 2002
Baptista Heloisa A, Avellar Maria C W, Araujo Ronaldo C, Pesquero Jorge L, Schanstra Joost P, Bascands Jean L, Esteve Jean P, Paiva Antonio C M, Bader Michael, Pesquero João B
Abstract excerpt
Kinins are involved in a variety of physiological and pathophysiological processes related to cardiovascular homeostasis, inflammation, blood flow, and nociception. Under physiological conditions, the bradykinin B2 (BKB2) receptor is constitutively expressed and mediates most of kinins' actions. However, the mechanisms regulating BKB2 receptor gene expression are still poorly understood. In this study, 4.6...
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