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Article

Autoregulation of Connexin43 Gap Junction Formation by Internally Translated Isoforms

1 Nov 2013

Abstract excerpt

During each heartbeat, intercellular electrical coupling via connexin43 (Cx43) gap junctions enables synchronous cardiac contraction. In failing hearts, impaired Cx43 trafficking reduces gap junction coupling, resulting in arrhythmias. Here we report that internal translation within Cx43 (GJA1) mRNA occurs, resulting in truncated isoforms that autoregulate Cx43 trafficking. We find that at least four truncated...

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PMID: 24210816
DOI: 10.1016/j.celrep.2013.10.009

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