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Article

Fate of connexin43 in cardiac tissue harbouring a disease-linked connexin43 mutant.

Cardiovascular research - 1 Dec 2008

Manias Janet L, Plante Isabelle, Gong Xiang-Qun, Shao Qing, Churko Jared, Bai Donglin, Laird Dale W

Abstract excerpt

AIMS: More than 40 mutations in the GJA1 gene encoding connexin43 (Cx43) have been linked to oculodentodigital dysplasia (ODDD), a pleiotropic, autosomal dominant disorder. We hypothesized that even with a significant reduction in the levels of Cx43 in a mutant mouse model of ODDD (Gja1(Jrt/+)) h...

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Source

Identifiers

PMID: 18678643
DOI: 10.1093/cvr/cvn203

Genes

GJA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18678643-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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