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Altered Expression of TMEM43 Causes Abnormal Cardiac Structure and Function in Zebrafish

23 Aug 2022

Abstract excerpt

Arrhythmogenic cardiomyopathy (ACM) is an inherited heart muscle disease caused by heterozygous missense mutations within the gene encoding for the nuclear envelope protein transmembrane protein 43 (TMEM43). The disease is characterized by myocyte loss and fibro-fatty replacement, leading to life-threatening ventricular arrhythmias and sudden cardiac death. However, the role of TMEM43 in the pathogenesis of ACM...

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PMID: 36076925
DOI: 10.3390/ijms23179530

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