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Article

Coordination of MYH DNA glycosylase and APE1 endonuclease activities via physical interactions.

DNA repair - 1 Dec 2013

Luncsford Paz J, Manvilla Brittney A, Patterson Dimeka N, Malik Shuja S, Jin Jin, Hwang Bor-Jang, Gunther Randall, Kalvakolanu Snigdha, Lipinski Leonora J, Yuan Weirong, Lu Wuyuan, Drohat Alexander C, Lu A-Lien, Toth Eric A

Abstract excerpt

MutY homologue (MYH) is a DNA glycosylase which excises adenine paired with the oxidative lesion 7,8-dihydro-8-oxoguanine (8-oxoG, or G(o)) during base excision repair (BER). Base excision by MYH results in an apurinic/apyrimidinic (AP) site in the DNA where the DNA sugar-phosphate backbone remains intact. A key feature of MYH activity is its physical interaction and coordination with AP endonuclease I (APE1),...

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Identifiers

PMID: 24209961
DOI: 10.1016/j.dnarep.2013.09.007
PMCID: PMC3857741

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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