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Article

Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair.

Molecular and cellular biology - 1 Feb 2009

Dherin Claudine, Gueneau Emeric, Francin Mathilde, Nunez Marcela, Miron Simona, Liberti Sascha Emilie, Rasmussen Lene Juel, Zinn-Justin Sophie, Gilquin Bernard, Charbonnier Jean-Baptiste, Boiteux Serge

Abstract excerpt

Mlh1 is an essential factor of mismatch repair (MMR) and meiotic recombination. It interacts through its C-terminal region with MutL homologs and proteins involved in DNA repair and replication. In this study, we identified the site of yeast Mlh1 critical for the interaction with Exo1, Ntg2, and...

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Source

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Identifiers

PMID: 19015241
DOI: 10.1128/MCB.00945-08
PMCID: PMC2630692

Genes

BLM
EXO1
MLH1
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19015241-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of a highly conserved binding site of Mlh1 required for exonuclease I-dependent mismatch repair.PMID 19015241Read ↗

Disruption of protein-protein interaction hotspots in the C-terminal domain of MLH1 confers mismatch repair deficiency.Semantic proximity Read ↗

Identification of MLH2/hPMS1 dominant mutations that prevent DNA mismatch repair function.Semantic proximity Read ↗

A conserved motif in the disordered linker of human MLH1 is vital for DNA mismatch repair and its function is diminished by a cancer family mutation.Semantic proximity Read ↗

DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair.Semantic proximity Read ↗

A mutation in EXO1 defines separable roles in DNA mismatch repair and post-replication repair.Semantic proximity Read ↗

Msh2 separation of function mutations confer defects in the initiation steps of mismatch repair.Semantic proximity Read ↗

Rad27 and Exo1 function in different excision pathways for mismatch repair in Saccharomyces cerevisiae.Semantic proximity Read ↗

Intrinsically disordered regions regulate both catalytic and non-catalytic activities of the MutLα mismatch repair complex.Semantic proximity Read ↗

exo1-Dependent mutator mutations: model system for studying functional interactions in mismatch repair.Semantic proximity Read ↗

Dominant mutations in S. cerevisiae PMS1 identify the Mlh1-Pms1 endonuclease active site and an exonuclease 1-independent mismatch repair pathway.Semantic proximity Read ↗

Mispair-specific recruitment of the Mlh1-Pms1 complex identifies repair substrates of the Saccharomyces cerevisiae Msh2-Msh3 complex.Semantic proximity Read ↗

Analysis of yeast MSH2-MSH6 suggests that the initiation of mismatch repair can be separated into discrete steps.Semantic proximity Read ↗

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