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Article

The Association of ATG16L1 Variations with Clinical Phenotypes of Adult-Onset Still's Disease.

Genes - 11 Jun 2021

Hung Wei-Ting, Hung Shuen-Iu, Chen Yi-Ming, Hsieh Chia-Wei, Chen Hsin-Hua, Tang Kuo-Tung, Chen Der-Yuan, Lan Tsuo-Hung

Abstract excerpt

Adult-onset Still's disease (AOSD) is a rare autoinflammatory disease, which has elevated autophagosome levels regulated by autophagy-related gene (ATG) expression. We investigated the associations of ATG polymorphisms with AOSD susceptibility, clinical manifestations, and disease course. The six-candidate single-nucleotide polymorphisms (SNPs) involved in autophagy were genotyped using direct sequencing on...

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Identifiers

PMID: 34208077
DOI: 10.3390/genes12060904
PMCID: PMC8230810

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