Article
The transcription factor MAZR preferentially acts as a transcriptional repressor in mast cells and plays a minor role in the regulation of effector functions in response to FcεRI stimulation.
PloS one - 1 Jan 2013
Abramova Anastasia, Sakaguchi Shinya, Schebesta Alexandra, Hassan Hammad, Boucheron Nicole, Valent Peter, Roers Axel, Ellmeier Wilfried
Abstract excerpt
Mast cells are key players in type I hypersensitivity reactions in humans and mice and their activity has to be tightly controlled. Previous studies implicated the transcription factor MAZR in the regulation of mast cell function. To study the role of MAZR in mast cells, we generated a conditional Mazr allele and crossed Mazr (F/F) mice with the Vav-iCre deleter strain, which is active in all hematopoietic cells....
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