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Article

Genome-wide interaction study identifies RCBTB1 as a modifier for smoking effect on carotid intima-media thickness.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2014

Wang Liyong, Rundek Tatjana, Beecham Ashley, Hudson Barry, Blanton Susan H, Zhao Hongyu, Sacco Ralph L, Dong Chuanhui

Abstract excerpt

OBJECTIVE: Carotid intima-media thickness (cIMT), a marker for atherosclerosis, is affected by smoking and has substantial interindividual variation. We sought to identify the genetic moderators influencing the effect of smoking on cIMT. APPROACH AND RESULTS: With a multistage design using 722 379 single nucleotide polymorphisms (SNP), a genome-wide interaction study was performed in a discovery sample of 669...

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Source

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Identifiers

PMID: 24202307
DOI: 10.1161/ATVBAHA.113.302706
PMCID: PMC4380266

Genes

RCBTB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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