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Article

Painful neuropathies: the emerging role of sodium channelopathies.

Journal of the peripheral nervous system : JPNS - 1 Jun 2014

Brouwer Brigitte A, Merkies Ingemar S J, Gerrits Monique M, Waxman Stephen G, Hoeijmakers Janneke G J, Faber Catharina G

Abstract excerpt

Pain is a frequent debilitating feature reported in peripheral neuropathies with involvement of small nerve (Aδ and C) fibers. Voltage-gated sodium channels are responsible for the generation and conduction of action potentials in the peripheral nociceptive neuronal pathway where NaV 1.7, NaV 1.8, and NaV 1.9 sodium channels (encoded by SCN9A, SCN10A, and SCN11A) are preferentially expressed. The human genetic...

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Source

Identifiers

PMID: 25250524
DOI: 10.1111/jns5.12071

Genes

SCN9A
SCN10A
SCN11A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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