Article
Low frequency KRAS mutations in colorectal cancer patients and the presence of multiple mutations in oncogenic drivers in non-small cell lung cancer patients.
Cancer genetics - 1 Jan 2000
Jiang Liyan, Huang Jiaqi, Morehouse Chris, Zhu Wei, Korolevich Susana, Sui Dan, Ge Xiaoxiao, Lehmann Kim, Liu Zheng, Kiefer Christine, Czapiga Meggan, Su Xinying, Brohawn Philip, Gu Yi, Higgs Brandon W, Yao Yihong
Abstract excerpt
Intratumor heterogeneity can confound the results of mutation analyses in oncodriver genes using traditional methods thereby challenging the application of targeted cancer therapy strategies for patients Ultradeep sequencing can detect low frequency and expanded clonal mutations in primary tumors...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.