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Article

Current tests to evaluate HIV-1 coreceptor tropism

1 Mar 2009

Abstract excerpt

PURPOSE OF REVIEW: HIV-1 entry into target cells is a complex multistage process involving the envelope glycoprotein, primary cellular receptor CD4, and at least two main cellular coreceptors, CCR5 and CXCR4. The identification of the HIV-1 coreceptors led to the rapid development of several drug candidates that selectively block this interaction, that is, CCR5 or CXCR4 antagonists. Here, we review different...

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PMID: 19339953
DOI: 10.1097/coh.0b013e328322f973

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