Article
Exome sequencing identifies distinct mutational patterns in liver fluke-related and non-infection-related bile duct cancers.
Nature genetics - 1 Dec 2013
Chan-On Waraporn, Nairismägi Maarja-Liisa, Ong Choon Kiat, Lim Weng Khong, Dima Simona, Pairojkul Chawalit, Lim Kiat Hon, McPherson John R, Cutcutache Ioana, Heng Hong Lee, Ooi London, Chung Alexander, Chow Pierce, Cheow Peng Chung, Lee Ser Yee, Choo Su Pin, Tan Iain Bee Huat, Duda Dan, Nastase Anca, Myint Swe Swe, Wong Bernice Huimin, Gan Anna, Rajasegaran Vikneswari, Ng Cedric Chuan Young, Nagarajan Sanjanaa, Jusakul Apinya, Zhang Shenli, Vohra Priya, Yu Willie, Huang DaChuan, Sithithaworn Paiboon, Yongvanit Puangrat, Wongkham Sopit, Khuntikeo Narong, Bhudhisawasdi Vajaraphongsa, Popescu Irinel, Rozen Steven G, Tan Patrick, Teh Bin Tean
Abstract excerpt
The impact of different carcinogenic exposures on the specific patterns of somatic mutation in human tumors remains unclear. To address this issue, we profiled 209 cholangiocarcinomas (CCAs) from Asia and Europe, including 108 cases caused by infection with the liver fluke Opisthorchis viverrini and 101 cases caused by non-O. viverrini-related etiologies. Whole-exome sequencing (n = 15) and prevalence screening...
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