Exome sequencing of liver fluke-associated cholangiocarcinoma.

doi:10.1038/ng.2273

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Article

Exome sequencing of liver fluke-associated cholangiocarcinoma.

Nature genetics - 6 May 2012

Ong Choon Kiat, Subimerb Chutima, Pairojkul Chawalit, Wongkham Sopit, Cutcutache Ioana, Yu Willie, McPherson John R, Allen George E, Ng Cedric Chuan Young, Wong Bernice Huimin, Myint Swe Swe, Rajasegaran Vikneswari, Heng Hong Lee, Gan Anna, Zang Zhi Jiang, Wu Yingting, Wu Jeanie, Lee Ming Hui, Huang DaChuan, Ong Pauline, Chan-on Waraporn, Cao Yun, Qian Chao-Nan, Lim Kiat Hon, Ooi Aikseng, Dykema Karl, Furge Kyle, Kukongviriyapan Veerapol, Sripa Banchob, Wongkham Chaisiri, Yongvanit Puangrat, Futreal P Andrew, Bhudhisawasdi Vajarabhongsa, Rozen Steve, Tan Patrick, Teh Bin Tean

Abstract excerpt

Opisthorchis viverrini-related cholangiocarcinoma (CCA), a fatal bile duct cancer, is a major public health concern in areas endemic for this parasite. We report here whole-exome sequencing of eight O. viverrini-related tumors and matched normal tissue. We identified and validated 206 somatic mut...

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Source

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Identifiers

PMID: 22561520
DOI: 10.1038/ng.2273

Genes

GNAS
KRAS
PEG3
RNF43
ROBO2
SMAD4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22561520-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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