Article
A NIMA-Related Kinase Suppresses the Flagellar Instability Associated with the Loss of Multiple Axonemal Structures.
PLoS genetics - 1 Sept 2015
Lin Huawen, Zhang Zhengyan, Guo Suyang, Chen Fan, Kessler Jonathan M, Wang Yan Mei, Dutcher Susan K
Abstract excerpt
CCDC39 and CCDC40 were first identified as causative mutations in primary ciliary dyskinesia patients; cilia from patients show disorganized microtubules, and they are missing both N-DRC and inner dynein arms proteins. In Chlamydomonas, we used immunoblots and microtubule sliding assays to show that mutants in CCDC40 (PF7) and CCDC39 (PF8) fail to assemble N-DRC, several inner dynein arms, tektin, and CCDC39....
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