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Article

Vpr expression abolishes the capacity of HIV-1 infected cells to repair uracilated DNA

30 Oct 2013

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) Vpr protein binds to the cellular uracil-DNA glycosylase UNG2 and induces its degradation through the assembly with the DDB1-CUL4 ubiquitin ligase complex. This interaction counteracts the antiviral activity exerted by UNG2 on HIV-1 gene transcription, as previously reported by us. In this work, we show that Vpr expression in the context of HIV-1 infection markedly...

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PMID: 24178031
DOI: 10.1093/nar/gkt974

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