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Uracil DNA Glycosylase 2 negatively regulates HIV-1 LTR transcription

20 Aug 2009

Abstract excerpt

Numerous cellular factors belonging to the DNA repair machineries, including RAD18, RAD52, XPB and XPD, have been described to counteract human immunodeficiency virus type 1 (HIV-1) replication. Recently, Uracil DNA glycosylase 2 (UNG2), a major determinant of the uracil base excision repair pathway, was shown to undergo rapid proteasome-dependent degradation following HIV-1 infection. However, the specific role...

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PMID: 19696076
DOI: 10.1093/nar/gkp673

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