Article
Genetic Variation in Autophagy-Related Genes Influences the Risk and Phenotype of Buruli Ulcer.
PLoS neglected tropical diseases - 1 Apr 2016
Capela Carlos, Dossou Ange Dodji, Silva-Gomes Rita, Sopoh Ghislain Emmanuel, Makoutode Michel, Menino João Filipe, Fraga Alexandra Gabriel, Cunha Cristina, Carvalho Agostinho, Rodrigues Fernando, Pedrosa Jorge
Abstract excerpt
INTRODUCTION: Buruli ulcer (BU) is a severe necrotizing human skin disease caused by Mycobacterium ulcerans. Clinically, presentation is a sum of these diverse pathogenic hits subjected to critical immune-regulatory mechanisms. Among them, autophagy has been demonstrated as a cellular process of critical importance. Since microtubules and dynein are affected by mycolactone, the critical pathogenic exotoxin...
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