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XBP1 variant 1 promotes mitosis of cancer cells involving upregulation of the polyglutamylase TTLL6

11 Jan 2022

Abstract excerpt

XBP1 variant 1 (Xv1) is the most abundant XBP1 variant and is highly enriched across cancer types but nearly none in normal tissues. Its expression is associated with poor patients' survival and is specifically required for survival of malignant cells, but the underlying mechanism is not known. Here we report that Xv1 upregulates the polyglutamylase tubulin tyrosine ligase-like 6 (TTLL6) and promotes mitosis of...

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PMID: 35333353
DOI: 10.1093/hmg/ddac010

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