Rodent models of leptin receptor deficiency are less sensitive to amylin.

Abstract excerpt

The pancreatic hormone amylin is released from beta cells following nutrient ingestion and contributes to the control of body weight and glucose homeostasis. Amylin reduces food intake by activating neurons in the area postrema (AP). Amylin was also shown to synergize with the adipokine leptin, with combination therapy producing greater weight loss and food intake reduction than either hormone alone. Although...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Feeding Behavior
• Share to Islet Amyloid Polypeptide