Article
Genetic determinants of haemolysis in sickle cell anaemia.
British journal of haematology - 1 Apr 2013
Milton Jacqueline N, Rooks Helen, Drasar Emma, McCabe Elizabeth L, Baldwin Clinton T, Melista Efi, Gordeuk Victor R, Nouraie Mehdi, Kato Gregory R, Kato Gregory J, Minniti Caterina, Taylor James, Campbell Andrew, Luchtman-Jones Lori, Rana Sohail, Castro Oswaldo, Zhang Yingze, Thein Swee Lay, Sebastiani Paola, Gladwin Mark T, Steinberg Martin H
Abstract excerpt
Haemolytic anaemia is variable among patients with sickle cell anaemia and can be estimated by reticulocyte count, lactate dehydrogenase, aspartate aminotransferase and bilirubin levels. Using principal component analysis of these measurements we computed a haemolytic score that we used as a subphenotype in a genome-wide association study. We identified in one cohort and replicated in two additional cohorts the...
Topics
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Alleles
- Anemia, Sickle Cell
- Child
- Cohort Studies
- Female
- GTPase-Activating Proteins