Biomarkers and genetic modulators of cerebral vasculopathy in sub-Saharan ancestry children with sickle cell anemia.

doi:10.1016/j.bcmd.2020.102436

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Article

Biomarkers and genetic modulators of cerebral vasculopathy in sub-Saharan ancestry children with sickle cell anemia.

Blood cells, molecules & diseases - 1 Jul 2020

Silva Marisa, Vargas Sofia, Coelho Andreia, Ferreira Emanuel, Mendonça Joana, Vieira Luís, Maia Raquel, Dias Alexandra, Ferreira Teresa, Morais Anabela, Soares Isabel Mota, Lavinha João, Silva Rita, Kjöllerström Paula, Faustino Paula

Abstract excerpt

We investigated biomarkers and genetic modulators of the cerebral vasculopathy (CV) subphenotype in pediatric sickle cell anemia (SCA) patients of sub-Saharan African ancestry. We found that one VCAM1 promoter haplotype (haplotype 7) and VCAM1 single nucleotide variant rs1409419_T were associated with stroke events, stroke risk, as measured by time-averaged mean of maximum velocity in the middle cerebral artery,...

Topics

Adolescent
Africa South of the Sahara
Anemia, Sickle Cell
Case-Control Studies
Child
Child, Preschool
Female
Genetic Markers
Genetic Predisposition to Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Haplotypes

Humans

Male

Phosphoric Diester Hydrolases

Polymorphism, Single Nucleotide

Pyrophosphatases

Stroke

Vascular Cell Adhesion Molecule-1

Source

Open in PubMed

Identifiers

PMID: 32434137
DOI: 10.1016/j.bcmd.2020.102436

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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