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Article

Genetic polymorphism of SMAD5 is associated with Kawasaki disease.

Pediatric cardiology - 1 Apr 2014

Cho Ja Hyang, Han Mi Young, Cha Sung Ho, Jung Joo Ho, Yoon Kyung Lim

Abstract excerpt

Mothers against decapentaplegic homolog (SMAD) proteins are intracellular mediators of members of the transforming growth factor-β (TGF-β) superfamily, which are activated by bone morphogenetic proteins (BMPs). On activation, SMAD5 forms heterometric SMAD complexes, which are translated to the nucleus where they regulate gene transcription. TGF-β induces T cell activation and cardiovascular disease, two important...

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Source

Identifiers

PMID: 24163009
DOI: 10.1007/s00246-013-0826-x

Genes

SMAD5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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