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Article

Genetic variants of ADAM17 are implicated in the pathological process of Kawasaki disease and secondary coronary artery lesions via the TGF-β/SMAD3 signaling pathway.

European journal of pediatrics - 1 May 2016

Peng Qian, Deng Yan, Yang Xiling, Leng Xiangyou, Yang Yuan, Liu Hanmin

Abstract excerpt

UNLABELLED: Kawasaki disease (KD) is a systemic vasculitis childhood disease frequently complicating coronary artery lesions (CALs). Recently, the gene encoding a disintegrin and metalloprotease 17 (ADAM17) was found to modify vascular pathology in humans by differentially regulating the transforming growth factor-β (TGF-β) signaling pathway, which affects KD/CAL susceptibility. To explore the potential role of...

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Source

Identifiers

PMID: 26833052
DOI: 10.1007/s00431-016-2696-8

Genes

ADAM17
SMAD3
TGFB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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