Article
Transforming growth factor-beta signaling pathway in patients with Kawasaki disease.
Circulation. Cardiovascular genetics - 1 Feb 2011
Shimizu Chisato, Jain Sonia, Davila Sonia, Hibberd Martin L, Lin Kevin O, Molkara Delaram, Frazer Jeffrey R, Sun Shelly, Baker Annette L, Newburger Jane W, Rowley Anne H, Shulman Stanford T, Davila Sonia, Burgner David, Breunis Willemijn B, Kuijpers Taco W, Wright Victoria J, Levin Michael, Eleftherohorinou Hariklia, Coin Lachlan, Popper Stephen J, Relman David A, Fury Wen, Lin Calvin, Mellis Scott, Tremoulet Adriana H, Burns Jane C
Abstract excerpt
BACKGROUND: Transforming growth factor (TGF)-β is a multifunctional peptide that is important in T-cell activation and cardiovascular remodeling, both of which are important features of Kawasaki disease (KD). We postulated that variation in TGF-β signaling might be important in KD susceptibility and disease outcome. METHODS AND RESULTS: We investigated genetic variation in 15 genes belonging to the TGF-β pathway...
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