Article

Consistent MYORG and STRADB Downregulation in DMD and LGMD: Rationale for Deoxygalactonojirimycin Repurposing in Dystrophic and Aging Muscle

2026-06-21

Abstract excerpt

<h4>Background</h4> MYORG (myogenesis-regulating glycosidase) and STRADB (STE20-related kinase adapter protein beta) were previously identified as activity-mediated skeletal muscle genes with potential roles in frailty and sarcopenia. We hypothesized that, if these genes are sustained by neuromuscular contractile activity, their expression should be consistently downregulated in muscular dystrophies, conditions d...

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Literature Corpus work: 4a0ae7da-c361-5ae7-a6be-2a214d38c576
DOI: 10.64898/2026.06.17.732878

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Consistent MYORG and STRADB Downregulation in DMD and LGMD: Rationale for Deoxygalactonojirimycin Repurposing in Dystrophic and Aging MuscleDOI 10.64898/2026.06.17.732878Read

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