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Purported Mcl-1 inhibitor marinopyrrole A fails to show selective cytotoxicity for Mcl-1-dependent cell lines

24 Oct 2013

Abstract excerpt

Anti-apoptotic Bcl-2 family proteins Bcl-2, Bcl-xL, and Mcl-1 have become prime targets for anti-cancer agents in an effort to overcome blocks in apoptosis exhibited by cancer cells. 1 Marinopyrrole A, a marine natural product originally developed for its activity against Methicillin-resistant Staphylococcus aureus , 2 , 3 was recently reported by Doi et al. 4 to be a selective Mcl-1 antagonist that binds to...

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PMID: 24157874
DOI: 10.1038/cddis.2013.411

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