Article
Small-molecule MDM2 inhibitor LQFM030-induced apoptosis in p53-null K562 chronic myeloid leukemia cells.
Fundamental & clinical pharmacology - 1 Aug 2020
de Oliveira Ribeiro Higor, Cortez Alane Pereira, de Ávila Renato Ivan, da Silva Artur Christian Garcia, de Carvalho Flávio Silva, Menegatti Ricardo, Lião Luciano Morais, Valadares Marize Campos
Abstract excerpt
Our group designed and synthesized the N-phenyl-piperazine LQFM030 [1-(4-((1-(4-chlorophenyl)-1H-pyrazol-4-yl)methyl) piperazin-1-yl) ethanone], a small molecule derived from molecular simplification of the Nutlin-1, an inhibitor of the human homologue of murine double minute 2 (MDM2) protein that is expressed in several types of cancer. To better investigate the effects of LQFM030 regarding the p53 mutation...
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