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Article

Reporter mutation studies show that nicotinic acetylcholine receptor (nAChR) α5 Subunits and/or variants modulate function of α6*-nAChR.

The Journal of biological chemistry - 4 Nov 2011

Dash Bhagirathi, Chang Yongchang, Lukas Ronald J

Abstract excerpt

To further the understanding of functional α6α5*-nicotinic acetylcholine receptors (nAChR; the asterisk (*) indicates known or possible presence of other subunits), we have heterologously expressed in oocytes different, mouse or human, nAChR subunit combinations. Coexpression with wild-type α5 subunits or chimeric α5/β3 subunits (in which the human α5 subunit N-terminal, extracellular domain is linked to the...

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Identifiers

PMID: 21873428
DOI: 10.1074/jbc.M111.264044
PMCID: PMC3207434

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