Article
Behavioral phenotypes and pharmacology in genetic mouse models of Parkinsonism.
Behavioural pharmacology - 1 Sept 2006
Fleming Sheila M, Chesselet Marie-Françoise
Abstract excerpt
Prior to the discovery of genes associated with familial forms of Parkinson's disease, animal models of Parkinson's disease mainly consisted of toxin models based exclusively on the degeneration of nigrostriatal dopamine neurons. These traditional models have provided valuable insight into symptomatic treatments for Parkinson's disease; however, they lack the broad extra-nigral pathology and the progression that...
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