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Article

Association of the CYP2B6 c.516G>T polymorphism with high blood propofol concentrations in women from northern Greece.

Drug metabolism and pharmacokinetics - 1 Jan 2014

Mastrogianni Orthodoxia, Gbandi Emma, Orphanidis Amvrosios, Raikos Nikolaos, Goutziomitrou Evangelia, Kolibianakis Efstratios M, Tarlatzis Basil C, Goulas Antonis

Abstract excerpt

Cytochrome P450 2B6 (CYP2B6) is responsible for the initial biotransformation of profol, an extensively metabolized intravenous anesthetic. In this study we examined the effect of the apparently functional CYP2B6 c.516G>T polymorphism on the distribution of propofol concentrations, quantified by GC/MS analysis following a single bolus dose, in the blood of 44 Greek women undergoing oocyte retrieval. Univariate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24153159
DOI: 10.2133/dmpk.dmpk-13-nt-092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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